By jointly identifying and validating promising biological targets of disease, the partnership strives to increase the number of new diagnostics and therapies for patients and reduce the time and cost of developing them. FNIH Biomarkers Consortium The Biomarkers Consortium is a public-private biomedical research partnership managed by the Foundation for the National Institutes of Health that endeavors to discover, develop, and qualify biological markers biomarkers to support new drug development, preventive medicine, and medical diagnostics.
By policy, the American Diabetes Association does not list or promote specific clinical trials other than the trials above in which it is a formal collaborator. This policy also applies to patient surveys.
There are far too many trials and surveys being conducted at any given time for the Association to be able to evaluate them on an individual basis.
However, the following resources from the Food and Drug Administration and the National Institutes of Health provide more information about clinical trials and how to determine which trials are being conducted in a location near you.
Department of Health and Human Services, is the nation's medical research agency—making important discoveries that improve health and save lives. A tertiary aim of the study is to compare the hospitalization rates of type 2 diabetes rates who were referred to onsite pharmacist services for management of their diabetes to similar patients The purpose of this study is to identify risk factors for ICI associated diabetes mellitus and to assess the severity and natural course of this immune related adverse effect.
To explore the feasibility of conducting a family centered wellness coaching program for patients at high risk for developing diabetes, in a primary care setting. To assess whether a family centered 8 week wellness coaching intervention for primary care patients at high risk for diabetes will improve self-care behaviors as measured by self-reported changes in physical activity level and food choices.
This study is being done to understand metformin's mechanisms of action regarding glucose production, protein metabolism, and mitochondrial function. The purpose of this study is to learn more about if the medication, Entresto, could help the function of the heart and kidneys. The purpose of this study is to evaluate the impact of a digital storytelling intervention derived through a community-based participatory research CBPR approach on type 2 diabetes mellitus T2D outcomes among Hispanic adults with poorly controlled type 2 diabetes mellitus T2D in primary care settings through a randomized clinical trial.
Our goal in this pilot study is to test and develop a novel method that will accurately measure, in vivo, glucagon kinetics in healthy humans and generate preliminary data in type 1 diabetes T1DM subjects under overnight fasted conditions. The purpose of this study is to find the inheritable changes in genetic makeup that are related to the development of type 2 diabetes in Latino families.
This trial is a multi-center, adaptive, randomized, double-blind, placebo- and active- controlled, parallel group, phase 2 study in subjects with Type 2 Diabetes Mellitus to evaluate the effect of TTP on HbA1c following administration for 6 months. The purpose of this study is to evaluate glucose variability in patients with type 1 diabetes T1D and insulin antibodies, to evaluate the clinical significance of insulin antibodies, and to establish an in vitro assay that would detect antibodies to insulin and insulin analogs.
This clinical trial will identify exercise-related and emotional stress related effects on glycemic control in patients with type 1 diabetes using sensor-augmented pump SAP therapy. The objective of this study is to evaluate the EWIS in patients with type 1 diabetes on insulin pump therapy.
This study is a multi-center, non-randomized, prospective single arm study with type 1 patients with diabetes on insulin pump therapy with Continuous Glucose Monitoring CGM. A total of up to subjects will be enrolled at up to 20 investigational centers in the US in order to have subjects meeting eligibility criteria.
Each subject will be given 12 infusion sets to wear each infusion set for at least hours, or The purpose of this research is to test the safety and effectiveness of the interoperable Artificial Pancreas System Smartphone App iAPS in managing blood sugars in pregnant patients with type 1 diabetes.
This observational study is conducted to determine how the duodenal layer thicknesses mucosa, submucosa, and muscularis vary with several factors in patients with and without type 2 diabetes.
The purpose of this study is to use the USS Virginia Closed-Loop system for overnight insulin delivery in adults with Type 1 Diabetes T1DM in an outpatient setting to evaluate the system's ability to significantly improve blood glucose levels. This protocol will test the feasibility of "bedside" closed-loop control - an approach comprised of standard sensor-augmented pump therapy during the day using off-the-shelf devices and overnight closed-loop control using experimental devices in an outpatient setting.
The rationale for this study is as follows: we anticipate that closed-loop control may ultimately be adopted by patients with T1DM in a selective manner. This mixed methods study aims to answer the question: "What is the work of being a patient with type 2 diabetes mellitus? The GRADE Study is a pragmatic, unmasked clinical trial that will compare commonly used diabetes medications, when combined with metformin, on glycemia-lowering effectiveness and patient-centered outcomes.
The purpose of this study is to assess whether psyllium is more effective in lowering fasting blood sugar and HbA1c, and to evaluate the effect of psyllium compared to wheat dextrin on the following laboratory markers: LDL-C, inflammatory markers such as ceramides and hsCRP, and branch chain amino acids which predict Diabetes Mellitus DM. The purpose of this study is to serve as a comparator group to a group of patients that will be managed with AP for varying periods of time during pregnancy.
The overall goal of this proposal is to determine the effects of acute hyperglycemia and its modulation by Glucagon-like Peptide-1 GLP-1 on myocardial perfusion in type 2 diabetes DM. This study plan utilizes myocardial contrast echocardiography MCE to explore a the effects of acute hyperglycemia on myocardial perfusion and coronary flow reserve in individuals with and without DM; and b the effects of GLP-1 on myocardial perfusion and coronary flow reserve during euglycemia and hyperglycemia in DM.
The investigators will recruit individuals with and without DM matched for age, gender and degree of obesity. The investigators will measure myocardial perfusion Hypothesis: Increased contact with the diabetes care team throughout pregnancy will lead to improved glucose control during pregnancy. The purpose of this study is to test the hypothesis that patients with T2DM will have greater deterioration in BMSi and in cortical porosity over 3 yrs as compared to sex- and age-matched non-diabetic controls; and identify the circulating hormonal e.
The purpose of this study is to assess the effectiveness of a digital storytelling intervention derived through a community based participatory research CBPR approach on self-management of type 2 diabetes T2D among Somali adults.
GLP-1 is a hormone made by the body that promotes the production of insulin in response to eating. Can QBSAfe be implemented in a clinical practice setting and improve quality of life, reduce treatment burden and hypoglycemia among older, complex patients with type 2 diabetes?
Retrospective chart review will also be done to assess objective diabetic control based on most recent hemoglobin A1c. The purpose of this study is to estimate the risk of diabetes related complications after total pancreatectomy. We will contact long term survivors after total pancreatectomy to obtain data regarding diabetes related end organ complications.
The purpose of this study is to understand nighttime glucose regulation in humans and find if the pattern is different in people with Type 2 diabetes. However, before we can implement structural changes or design interventions to promote comprehensive regenerative care in clinical practice, we first need to characterize those regenerative practices occurring today, patients expectations, perceptions and experiences about comprehensive regenerative care and determine the The purpose of this research is to create a single registry for type 1 diabetes at Mayo Rochester and affiliated Mayo sites.
The purpose of this study is to see if there is a connection between bad experiences in the patient's childhood, either by the patient or the parent, and poor blood sugar control, obesity, poor blood lipid levels, and depression in patients with type 1 diabetes. The purpose of this study is to assess the glycemic variability in patients with complex diabetes admitted in the hospital using a glycemic sensor. The purpose of this study is to determine the impact of patient decision aids compared to usual care on measures of patient involvement in decision-making, diabetes care processes, medication adherence, glycemic and cardiovascular risk factor control, and use of resources in nonurban practices in the Midwestern United States.
The purpose of this study is to evaluate if breathing pure oxygen overnight affects insulin sensitivity in participants with diabetes. This purpose of this study is to determine if activation of a person's immune system in the small intestine could be a contributing cause of Type 1 Diabetes. This study is being done to determine the roles that several molecules play in the repair of injured cells that line your blood vessels.
The purpose of this project is to collect data over the first year of clinical use of the FDA approved G closed loop insulin delivery system among patients with type 1 diabetes. The goal is to evaluate how this newly approved system impacts both clinical and patient-reported outcomes.
The objective of this study is to pilot-test this novel, scalable, and sustainable BeWell model that is embedded and integrated as part of primary care for Mayo Clinic Employees within Mayo Clinic Florida who are identified as patients li ving with poorly-controlled T2D.
It is unknown whether muscle free fatty acid FFA availability or intramyocellular fatty acid trafficking is responsible for muscle insulin resistance, although it has been shown that raising FFA with Intralipid can cause muscle insulin resistance within 4 hours.
We do not understand to what extent the incorporation of FFA into ceramides or diacylglycerols DG affect insulin signaling and muscle glucose uptake. We propose to alter the profile and concentrations of FFA of healthy, non-obese adults using an overnight, intra-duodenal palm oil infusion vs.
Exendin- 9,39 has been shown to have effects on beta-cell function, and after gastric bypass, to accelerate gastrointestinal transit. Given that gastrointestinal transit is typically delayed by Glucagon-Like Peptide-1 GLP-1 and also that this hormone causes decreased food intake through increased satiation, it is reasonable to expect an effect of Exendin-9,39 on appetite. This may help explain the effects of gastric bypass on food intake.
To examine the effect of Exendin on food intake we propose a dose-response study to determine whether the compound has effects in a dose-dependent fashion. We will examine the presence The purpose of this study is to evaluate the dose-dependent effects of TAK on gastric emptying time of solids in participants with diabetic or idiopathic gastroparesis assessed by scintigraphy. The purpose of this study is to gather preliminary data to better understand acute effects of exercise on glucose metabolism.
We will address if subjects with Type 1 Diabetes T1D are more insulin sensitive during and following a short bout of exercise compared to healthy controls. We will also determine insulin dependent and insulin independent effects on exercise in people with and without type 1 diabetes.
The study is being done to find out if low blood sugar hypoglycemia can be reduced in people with type 1 diabetes T1D 65 years and older with use of automated insulin delivery AID system. We will be collecting data about how they are used, how well they work, and how safe they are.
The objective for thisstudy is to characterize the impact of glycemic excursions on cognition in Type 1 Diabetes T1D and determine mediators and moderators of this relationship.
This study will allow us to determine how glycemic excursions impact cognition, as well as to identify mediators and moderators of this relationship that could lead to novel interventions. The purpose of this trial is to assess the performance of an Artificial Pancreas AP device using the Portable Artificial Pancreas System pAPS platform for subjects with type 1 diabetes using an insulin pump and rapid acting insulin.
This proposed study is designed to compare closed-loop control with or without optimization of initialization parameters related to basal insulin infusion rates and insulin to carbohydrate I:C ratios for meals and snacks. The study consists of an evaluation of the Artificial Pancreas device system during two Prior to the closed-loop phases, each subject will undergo The primary goal of this study protocol is to determine the candidate ratio of pramlintide and insulin co-infusion in individuals with type 1 diabetes T1DM to enable stable glucose control during the overnight post-absorptive and in the postprandial periods.
The study is designed to understand the confidence and competence level of patients with type 1 diabetes mellitus in their ability to make changes to their insulin pump.
The investigators previously found that Asian Indian immigrants have high mitochondrial capacity in spite of severe insulin resistance. Somalians are another new immigrant population with rapidly increasing prevalence of diabetes. Both of these groups traditionally consume low caloric density diets, and the investigators hypothesize that when these groups are exposed to high-calorie Western diets, they exhibit increased oxidative stress, oxidative damage, and insulin resistance.
The investigators will This study aims to identify an early stage biomarker for type 1 diabetes. Peter Buchwald, Ph. George W. Burke, III, M. Diego Correa, M. Chris Fraker, Ph. Interview: Under the Microscope Ronald B. Goldberg, M. Norma S. Kenyon, Ph. Thomas Malek, Ph. Daniel H. Mintz, M. Bresta Miranda, M. Ricardo Pastori, Ph. Alberto Pugliese, M. Jay S. Skyler, M. Maria Del Pilar Solano, M. Alice Tomei, Ph. Sign Up for e-news Search: Search.
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