Vaccine epstein barr virus ebv

While EBV infection in early childhood is predominantly asymptomatic, primary infection in adolescence can lead to infectious mononucleosis IM , a clinical syndrome including fever, fatigue, sore throat, and lymphadenopathy.

IM can debilitate patients for weeks to months, sometimes requiring hospitalization for serious complications such as splenic rupture and significant airway compromise. Most recently, Moderna's capabilities have come together to allow the authorized use of one of the earliest and most-effective vaccines against the COVID pandemic. Moderna's mRNA platform builds on continuous advances in basic and applied mRNA science, delivery technology and manufacturing, and has allowed the development of therapeutics and vaccines for infectious diseases, immuno-oncology, rare diseases, cardiovascular diseases, and auto-immune diseases.

Upon reactivation of the latent virus within the host, EBV is repeatedly stimulated, which may correlate with the onset of MS or its symptoms. Epstein-Barr virus may be leading cause of multiple sclerosis. January 13, Alana Hippensteele, Managing Editor. Abstract Epstein-Barr virus EBV is the primary cause of infectious mononucleosis and is associated with several malignancies, including nasopharyngeal carcinoma, gastric carcinoma, Hodgkin lymphoma, Burkitt lymphoma, and lymphomas in immunocompromised persons, as well as multiple sclerosis.

Publication types Research Support, N. Substances Herpesvirus Vaccines. David Hurley, Ph. Young said that in most people, EBV becomes dormant again following a reactivation. However, in rare cases, it can cause long-term health problems. A phase 1 clinical trial of an EBV vaccine recently started to test its safety and immune responses in volunteers.

In theory, such a vaccine could protect people against severe illness and long-term health effects of EBV reactivation. Hurley remains skeptical, however. He told MNT that there are no effective vaccines against the closely related herpes simplex viruses 1 or 2, despite decades of research. This virus lies dormant in immune cells, nerve cells, and epithelial cells , but stressors can reactivate it.

In rare cases, this can cause cancer.